Research Overview

My research focuses on computational chemistry approaches to understand nanoscale phenomena. Combining molecular dynamics simulations with machine learning techniques, I investigate self-assembly processes, biomolecular interactions, and catalytic mechanisms at atomic resolution.

Nanocluster Self-Assembly

Investigating the thermodynamic drivers of metal nanocluster assembly using enhanced sampling techniques. Developing machine-learned potentials to simulate assembly pathways over extended timescales. Current work focuses on ligand-mediated assembly mechanisms and their response to environmental stimuli.

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Biomolecule-Nanocluster Interactions

Characterizing interaction dynamics between proteins and monolayer-protected clusters through all-atom MD simulations. Developing collective variables to study binding thermodynamics and kinetics. Recent findings reveal sequence-dependent binding affinities with implications for biosensing applications.

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Catalytic Reaction Mechanisms

Elucidating reaction pathways in heterogeneous catalysis using metadynamics. Current focus on copper-iron bimetallic systems for C-H activation. Developing hybrid QM/ML approaches to achieve DFT-level accuracy in large-scale simulations of catalytic cycles.

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Conferences & Presentations

Feb 2025

PMRF Symposium 2025

IIT Hyderabad, India

Poster presentation

"Atomistic Details of Nanocluster Formation from Machine-Learned Potential-based Simulations"

Oct 2024

Physical Chemistry Symposium 2024

IIT Bombay, India

Poster presentation

"Modeling Enzyme-like Catalytic Reaction on Ligand-protected Metal Nanoclusters"

Sept 2024

AsiaNANO Conference

IIT Madras, Chennai, India

Oral presentation

"Dynamics and Self-Assembly of Atomically Precise Nanoclusters"

Aug 2024

ACS Fall Meeting 2024

Global Virtual Symposia (Online)

Oral presentation

"Modeling Enzyme-like Catalytic Reaction on Ligand-protected Metal Nanoclusters"

Feb 2024

MD@60 JNCASR-CECAM International Conference

JNCASR, Bengaluru, India

Poster presentation

"Investigating Enzyme-like Photocatalytic Oxidation on Ligand-protected Metal Nanoclusters"

July 2023

Enhanced Sampling Workshop

CECAM-HQ-EPFL, Lausanne, Switzerland

Workshop Attendee

"Hands-on training in PLUMED enhanced sampling techniques"

Dec 2022

CFOS-2022

IIT Roorkee, India

Poster presentation

"DFT study of pTSA catalyzed Friedel Craft's reaction revealing concerted mechanism along with cooperative effect of HFIP"

Nov 2022

IGWYR-2022

IIT Delhi, India

Poster presentation

"DFT study of pTSA catalyzed Friedel Craft's reaction revealing concerted mechanism along with cooperative effect of HFIP"

Dec 2021

MMM-II Conference

NISER Bhubaneswar (Online)

Poster presentation

"NaCl as catalyst and water as solvent: Highly E-selective olefination of methyl-substituted N-heteroarenes with benzyl amines and alcohols"